Liverpool can rub more salt into Manchester United wounds with a first victory at Old Trafford in five years on Sunday, while Man City will try to haul themselves back onto the leader’s coattails with victory at Crystal Palace.
Just eight games into the season, 15 points separates Liverpool at the top of the table from United down in 12th.
The European champions have shot into an eight-point lead even over their closest challengers in City, thanks to a run of 17 straight Premier League wins stretching back to last season.
By contrast, United have won just two of their last 13 league games.
Liverpool have not won on their past six visits to United and left-back Andy Robertson warned that form will not count for much given the historical rivalry between the sides.
City must bounce back to winning ways after a shock 2-0 home defeat to Wolves two weeks ago to at least apply some pressure on Liverpool when they visit Crystal Palace on Saturday.
The champions badly missed Kevin de Bruyne a fortnight ago and should have the Belgian international back from a groin strain as they look to become the first visiting side to win at Selhurst Park this season.
City have scored 25 goals in the six Premier League games De Bruyne has started this season, but been beaten in two matches he has not.
The international break may have come at the right time for Tottenham after a 3-0 thrashing at Brighton followed a humiliating 7-2 defeat by Bayern Munich in the Champions League.
Spurs have won just three of their opening 11 games in all competitions, but the visit of Watford this weekend could offer some blessed relief for Mauricio Pochettino’s men.
The Hornets are the only side yet to win in the league this season and sit rock bottom of the table having conceded 20 goals in their opening eight games.
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